Sanofi Covid vaccine delayed until end of 2021 – as UK has 60m doses on order

SANOFI’S Covid vaccine has flopped at the first hurdle.

The elderly did not produce a strong immune response to the vaccine in early trials.


Sanofi Covid vaccine delayed until end of 2021 – as UK has 60m doses on order
Sanofi’s Covid vaccine has flopped at the first hurdle.

In theory this would mean they would not be protected from disease.

But scientists believe they will be able to improve the formula and try again.

It’s likely to push back the final results of trials until the end of 2021, after being expected in the first half of the year.

The Department for Business, Energy and Industrial Strategy previously said the jab could be given to high-risk Britons as early as the first half of next year, if it passes trials. 

There are high hopes for the Sanofi vaccine, developed in partnership with the drug giant GSK.

The companies have the largest manufacturing capabilities in the world, and claim to be able to produce one billion doses a year.

The UK secured a deal for 60 million doses in July, enough for half the population, rumoured to cost £500 million.

At this point, ministers had no idea if any Covid candidate would work, but appeared to place bets on the Sanofi one.

Therefore the delay will come as a huge blow in the fight against the deadly virus.

However, Covid vaccination is now well underway in the UK, after the Pfizer/BioNTech jab started to be given out at NHS hospitals.

“Low response” in elderly

Results announced by Sanofi/GSK on Friday showed “a low immune response in older adults “.

The elderly are the most at risk of severe Covid-19 and death, and so it is crucial scientists work to find one that can protect them.

Adults aged 18 to 29 years old did show a response to the vaccine, however.

Scientists said it was not a surprise that the vaccine didn’t work in the older groups because their immune system is slower, and therefore needs a higher dose to work.

Jean-Daniel Lelievre, head of clinic immunology and infectious diseases at Henri-Mondor hospital in Creteil, France, told Reuters: “We know that more antigen is needed in older patients.

“But when in phase 1 and 2, drugmakers test tolerance and one cannot test strong dosages.”

He added: “I would think Sanofi and GSK will be able to improve their vaccine.”

Sanofi said a tweaked formulation had already shown better effects in animal studies.

Delays

The phase 3 study of the vaccine – the largest part which concludes if the virus prevents a person getting sick with Covid-19 – was due to start this month.

However, earlier phases will now need to be re-done, starting from February 2021.

The phase 3 studies will start between March and June of 2021, if the results are positive, which would lead to the data being given to regulators in “the second half of 2021”.

At the time of the Government’s deal in July, Roger Connor, president of GSK Vaccines, said: “We believe that this adjuvanted vaccine candidate has the potential to play a significant role in overcoming the Covid-19 pandemic, both in the UK and around the world.

“We thank the UK Government for confirmation of purchasing intent, which supports the significant investment we are already making as a company to scale up development and production of this vaccine.”

The news follows the start of the Covid-19 vaccine roll out in the UK, using the jab from Pfizer and BioNTech.

It was given regulatory approval from the MHRA last week, and already “tens of thousands” of Britons have been given the jab since December 8, the Health Secretary Matt Hancock said last night.

“As of today, we are vaccinating in 73 hospitals across the UK, tens of thousands of people have had the jab,” he said at a Downing Street news briefing on December 10.

The UK is the first country in the world to have an approved vaccine for the coronavirus.

And the Oxford/AstraZeneca jab could be the second approved within the coming weeks, with the MHRA currently looking at the data from trials.

The UK government has ordered 340 million doses of Covid-19 vaccines from several manufacturers, 40 million of which are from Pfizer and 100 million from Oxford.

The UK should have three or four vaccines against Covid-19 by the middle of next year, England’s chief medical officer has said.

Professor Chris Whitty told the Commons Health and Science Committee on December 9 that he expects to have a “portfolio” of several vaccines by the middle of 2021, but advised that the rollout process should still proceed “carefully”.